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- Bandey I et al. (2023) Overcoming migratory exhaustion: Expression of Matrix metalloproteinase-8 (MMP-8) promotes tumor infiltration and anti-tumor activity of CAR-T cells. bioRxiv PDF
- Saeedi A et al. (2022) Engineering non-cytotoxic delivery of proteins by T cells via fusion to NPC2. bioRxiv PDF
- Martinez-Paniagua M et al. (2022) Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy. bioRxiv PDF
Publications
- Steffin D et al. (2024) Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers. Nature PDF
- Wu KL et al. (2024) PostFocus: automated selective post-acquisition high-throughput focus restoration using diffusion model for label-free time-lapse microscopy. Bioinformatics PDF
- Leekha A et al. (2024) Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters. Nat Comm PDF
- Leekha A et al. (2024) An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models. Nat Comm PDF
- Acharya S et al. (2024) CD28 costimulation augments CAR signaling in NK cells via the LCK/CD3Z/ZAP70 signaling axis. Cancer Disc PDF
- Rezvan A et al. (2024) Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling. Nat Can PDF
- Kumar M et al. (2024) Enzymatic depletion of circulating glutamine is immunosuppressive in cancers. iScience PDF
- Sefat KMS et al. (2024) An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis. Vaccine PDF
- Kulkarni R et al. (2024) The efficient synthesis and purification of 2′3’- cGAMP from Escherichia coli. Frontiers in Microbio PDF
- Montalvo M et al. (2024) Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition. Cell Death & Dis PDF
- Wu KL et al. (2023) Automated detection of apoptotic bodies and cells in label-free time-lapse high-throughput video microscopy using deep convolutional neural networks. Bioinformatics PDF
- Fathi M et al. (2023) Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling. iScience PDF
- Li Y et al. (2022) KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape. Nat Med PDF
- Romain G et al. (2022) Multidimensional single-cell analysis identifies a role of CD2-CD58 interactions for clinical antitumor T cell responses. J Clin Invest PDF
- Fathi M et al. (2022) Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers. BioTechniques PDF
- Doshi A et al. (2022) Design and characterization of a salicylic acid-inducible gene expression system for Jurkat cells. Journal of Biotech PDF
- Sadeghi F et al. (2021) Salicylic acid inducible nucleocytoplasmic shuttling of NPR1 fusion proteins in human cells. Biotech Bioengineering PDF
- An X et al. (2021) Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2. iScience PDF
- Fathi M et al. (2021) Single-cell cloning of breast cancer cells secreting specific subsets of extracellular vesicles. Cancers PDF
- Joseph R et al. (2021) CD8+ T cells inhibit metastasis and CXCL4 regulates its function. British Journal of Cancer PDF
- Bandey I et al. (2021) Designed improvement to T-cell immunotherapy by multidimensional single cell profiling. Journal for ImmunoTherapy of Cancer PDF
- Yang D et al. (2021) Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils. PNAS PDF
- Zheng J et al. (2021) Single cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia. iScience PDF
- Daher M et al. (2021) CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor. Blood PDF
- Hou J et al. (2021) Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators. Journal for ImmunoTherapy of Cancer PDF
- Doshi A et al. (2020) Small-molecule inducible transcriptional control in mammalian cells. Crit Rev in Biotech PDF
- Rath J et al. (2020) Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αß -engineered human CD4+ T cells. Science Advances PDF
- Fousek R et al. (2020) CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression Leukemia PDF
- Mobiny A et al. (2020) Automated Classification of Apoptosis in Phase Contrast Microscopy Using Capsule Network IEEE Trans Med Imaging PDF
- Ramesh P et al. (2019) Engineered Chymotrypsin for Mass Spectrometry-Based Detection of Protein Glycosylation. ACS Chem Biol PDF
- Yuan P et al. (2019) Phasetime: Deep Learning Approach to Detect Nuclei in Time Lapse Phase Images J Clin Med PDF
- Varadarajan N and Mohan C (2019) Elucidating the molecular circuitry of autoimmunity Nat Immunol PDF
- Soundarajan R et al. (2019) Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy Cancers PDF
- Yankaskas C et al. (2019) A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens Nature Biomed Engineering PDF
- Mahendra A et al. (2019) Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing. Arthritis Rheumatol PDF
- Lu H et al. (2019) TIMING 2.0: high-throughput single-cell profiling of dynamic cell-cell interactions by time-lapse imaging microscopy in nanowell grids. Bioinformatics PDF
- An X, and Varadarajan N (2018) Single-cell technologies for profiling T cells to enable monitoring of immunotherapies. Curr Opin Chemical Engg PDF
- An X et al. (2017) Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells. Plos One PDF
- Ritthipichai K et al. (2017) Multifaceted role of BTLA in the control of CD8+ T cell fate after antigen encounter Clin Cancer Res PDF
- Varadarajan N (2017) Unmassked: Single-Cell Profiling of Immune Cell Populations in Tumors. Mol Ther PDF
- Lee CH et al. (2017) IgG Fc domains that bind C1q but not effector Fcg receptors delineate the importance of complement-mediated effector functions. Nat Immunol 196: 4075-4081 PDF
- Moogk D et al. (2016) Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol 196: 4075-4081 PDF
- Mahendra A et al. (2016) Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual’s Immune System: A Study on a Large Cohort of Renal Transplant Patients. J Immunol 196: 4075-4081. PDF
- Ramesh B; Frei CS; Cirino PC; Varadarajan N (2015) Functional enrichment by direct plasmid recovery after fluorescence activated cell sorting. Biotechniques 59(3), 157-161. PDF
- Merouane A et al. (2015) Automated and Quantitative Profiling of Individual Cell-Cell Interactions from High-throughput Time-lapse Imaging Microscopy in Nanowell Grids. (TIMING) Bioinformatics 31(19):3189-97. PDF
- Liadi I et al. (2015) Defining potency of CAR+ T cells: Fast and Furious or Slow and Steady. OncoImmunology doi: 10.1080/2162402X.2015.1051298 PDF
- Liadi I et al. (2015) Individual motile CD4+ T cells can participate in efficient multi-killing through conjugation to multiple tumor cells. Cancer Immunol Res 3(5):473-82. PDF
- Romain G et al. (2014) Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. Blood Nov 20;124(22):3241-9. PDF
- Ogunniyi AO et al. (2014) Profiling human antibody responses by integrated single-cell analysis. Vaccine May 19;32(24):2866-73. PDF
- Sendra VG, Lie A, Romain G, Agarwal SK, Varadarajan N (2013) Detection and isolation of auto-reactive human antibodies from primary B cells. Methods 2013 Dec 1;64(2):153-9. PDF
- Dekosky BJ et al. (2013) High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat Biotech 2013 Feb;31(2):166-9. PDF
- Liadi I et al. (2013) Quantitative High-Throughput Single-Cell Cytotoxicity Assay for T cells. J Vis Exp 2013 Feb 2;(72). PDF
- Ramesh B, Sendra VG, Cirino PC, Varadarajan N (2012) Single-cell characterization of autotransporter mediated Escherichia coli surface display of disulfide-bond containing proteins. J Biol Chem Nov 9;287(46):38580-9. PDF
- Skretas G et al. (2012). Multi-copy genes that enhance the yield of mammalian G Protein-coupled receptors in Escherichia coli. Metab Eng 2012 Sep;14(5):591-602. PDF
- Varadarajan N et al. (2012) Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A 109(10):3885-90. PDF
- Varadarajan N et al. (2011) A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest Nov 1;121(11):4322-31. PDF
- Varadarajan N, Pogson M, Georgiou G and Iverson BL (2009) Proteases That Can Distinguish among Different Post-translational Forms of Tyrosine Engineered Using Multicolor Flow Cytometry. J Am Chem Soc 131(50):18186-90. PDF
- Varadarajan N, Cantor J, Georgiou G and Iverson BL (2009) Construction and flow-cytometric screening of targeted enzyme libraries. Nat Prot 4(6):893-901. PDF
- Varadarajan N, Georgiou G, Iverson BL (2008) Engineered Proteases that Cleave Specifically after Sulfalted Tyrosine for the Detection of Post-Translationally Modified Peptides. Angew Chem Intl Ed 47(41):7861. PDF
- Varadarajan N et al. (2008) Highly Active and Selective Endopeptidases with Programmed Substrate Specificities. Nat Chem Biol 4(5):290-4. PDF
- Hwang BY et al. (2007) Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpP. J Bacteriol 189: 522-30. PDF
- Varadarajan N et al. (2005) Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity. Proc Natl Acad Sci U S A 102:6855-60. PDF
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